Welcome to Dean’s LaFerla Lab
The broad goal of my lab is to further the understanding of the pathophysiological mechanisms underlying neurological disorders such as Alzheimer’s disease, Lewy body dementia, and frontotemporal dementia, with the use of innovative transgenic modeling technology. All of these disorders are considered proteinopathies, and are marked by the accumulation of aggregated proteins such as Aß, phosphor-tau, or a-synuclein, and by profound neuronal and synaptic loss.
The goal of the proposed project is of high interest to my lab, and seeks to expand our understanding of the molecular relationship, and interaction, between Aß and tau, and their contribution to cognitive decline; which remains one of the most fundamental and unresolved questions in the AD field. Toward this end, we have developed several new, and exciting, transgenic models that add significantly to the field, and will enable us to dissect the molecular pathways by which Aß and tau interact, and the mechanisms by which they adversely impact cognition during different stages of the disease process.